Silver was prized for its ability to preserve food and water. Ancient Egyptians, Persians, and Greeks stored liquids in silver vessels to prevent spoilage. Silver coins were sometimes placed on wounds to reduce infection risk, although the mechanism was not understood.

Romans used powdered silver and silver nitrate as topical antiseptics for wounds and ulcers. Silver-infused salves were applied to promote healing, and silver goblets were valued for keeping water and wine fresh during long journeys.

Medieval healers used silver leaf to dress wounds, believing it prevented corruption of the flesh. Silver goblets and utensils were common among the wealthy, both as status symbols and for their ability to reduce disease transmission. Monasteries often incorporated silver in medicinal preparations.